
Discover breakthrough antibody therapeutics from elite human sera
We source elite human antibodies directly from biofluids, capturing nature's most potent immune defenses to fuel therapeutics that solve real patient needs.
Discovering Breakthrough Antibodies from Elite Human Sera, Turning Natural Immunity into Lifesaving Medicine
We source elite human antibodies directly from biofluids, capturing nature's most potent immune defenses to fuel therapeutics that solve real patient needs.
Elite human antibodies: nature’s blueprint for therapeutics

Sourcing therapeutics from exceptional human antibodies with superior efficacy and safety
At Abvion, we source antibodies directly from the serum of individuals with exceptional immune responses. This includes elite responders with superior disease recovery and people producing other valuable antibodies. Such antibodies represent serological prototypes: highly effective, well-tolerated molecules ideal as starting points for therapeutics.
Our protein-level discovery approach captures these valuable antibodies directly from biofluids, including archived biobank materials. It delivers fully mature, in vivo optimized antibodies, the functional molecules themselves, which are inaccessible to single-cell NGS approaches. This enables faster, more precise development of therapies with superior efficacy and safety, setting a new standard in human-derived antibody therapies.
AbDirect: antibody discovery with protein-level precision

Proteomics-based antibody discovery delivers maximal insights from minimal sample amounts
Our AbDirect platform leverages advanced proteomics and mass spectrometry to transform antibody discovery for biopharma innovations. This function-driven approach starts by identifying biofluids with a promising activity. By upfront repertoire screening, we evaluate over 1,000 target-specific antibodies in each sample for reactivity and specificity.
Our standalone de novo sequencing approach achieves pinpoint accuracy in identifying pre-selected antibodies from complex materials. It excels in accurate chain pairing and detecting fine details, including isotype, modifications, and single mutations within clonal families. This protein-level precision streamlines antibody discovery pipelines, delivering high-quality panels ready for development.

Collaboration
Partnering with Abvion to accelerate innovation
Abvion partners with biopharma and academia to drive antibody discovery forward. We offer flexible engagements, from lower-commitment pilots to research collaborations, tailored to project stage and goals. Contact us to learn more and explore opportunities for accelerating your ideas and pipeline.
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Human Plasma IgG1 Repertoires are Simple, Unique, and Dynamic
Bondt et al., 2021, Cell Systems 12, 1131-113
Discriminating cross-reactivity in polyclonal IgG1 responses against SARS-CoV-2 variants of concern
Van Rijswijck et al., 2022, Nature Communications 13, 6103
Stork et al., 2024, Nature Communications 15, 3114
Selectivity over coverage in de novo sequencing of IgGs
Den Boer et al., 2020, Chemical Science 11, 11886-11896
High-Resolution Native Mass Spectrometry
Tamara et al., 2021, Chemical Reviews 122, 8, 7269-7326

Scientific excellence
Built on award-winning research, we relentlessly push the boundaries of possibility
Our work builds on the pioneering work of professor Albert Heck at Utrecht University. His contributions to the fields of bioanalytical chemistry and proteomics have been awarded with multiple scientific accolades. These include the Spinoza Prize, Krebs Medal, and Thomson Medal.
